Overview

  • Product name

    Phallacidin, F-actin filament stabilizing agent
  • Description

    Selective F-actin filament stabilizing agent
  • Biological description

    Selective F-actin filament stabilizing agent. Shows similar biological actions to Phalloidin (ab143533). Prevents the dissociation of paired filaments. Impairs mast cell degranulation.
  • Purity

    > 98%
  • CAS Number

    26645-35-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Cyclic(L-Alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl-L-valyl-erythro-3-hydroxy-D-alpha-aspartyl-L-cysteinyl-cis-4-hydroxy-L-prolyl) cyclic (2-6)-sulfide
  • Molecular weight

    846.91
  • Molecular formula

    C37H50N8O13S
  • PubChem identifier

    3034055
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1C(=O)NC2CC3=C(NC4=CC=CC=C34)SCC(C(=O)N5CC(CC5C(=O)N1)O)NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CC(C)(CO)O)C(C)C)C(C(=O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Schmid E  et al. Serum- and glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation. Am J Physiol Cell Physiol 304:C49-55 (2013). Read more (PubMed: 23015548) »
  • al-Mohanna FA & Hallett MB Actin polymerization in neutrophils is triggered without a requirement for a rise in cytoplasmic Ca2+. Biochem J 266:669-74 (1990). Read more (PubMed: 2158299) »
  • Detmers PA  et al. Localization of actin in Chlamydomonas using antiactin and NBD-phallacidin. Cell Motil 5:415-30 (1985). Read more (PubMed: 2415259) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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