Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab6093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes
    Stable for one year.


    Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

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Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Acidic (leucine rich) nuclear phosphoprotein 32 family member B
    • Acidic leucine rich nuclear phosphoprotein 32 family member B
    • Acidic leucine-rich nuclear phosphoprotein 32 family member B
    • Acidic nuclear phosphoprotein 32 family member B
    • Acidic protein rich in leucines
    • AN32B_HUMAN
    • ANP 32B
    • ANP32B
    • APRIL
    • OTTHUMP0000006377
    • PAL 31
    • PAL31
    • PHAPI 2
    • PHAPI2
    • PHAPI2 protein
    • PHAPI2a
    • Proliferation related acidic leucine rich protein
    • Putative HLA-DR-associated protein I-2
    • Silver stainable protein SSP 29
    • Silver stainable protein SSP29
    • Silver-stainable protein SSP29
    • Ssp 29
    • Ssp29
    see all
  • Function
    Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
  • Tissue specificity
    Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.
  • Sequence similarities
    Belongs to the ANP32 family.
    Contains 4 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
  • Domain
    Histone binding is mediated by the concave surface of the LRR region.
  • Post-translational
    modifications
    Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.
  • Cellular localization
    Nucleus. Accumulates in the nuclei at the S phase and Cytoplasm. Lacks a nuclear localization signal.
  • Information by UniProt

References

ab6093 has not yet been referenced specifically in any publications.

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