PHAPI2 / APRIL peptide (ab6093)
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Overview
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Product namePHAPI2 / APRIL peptide
See all PHAPI2 / APRIL proteins and peptides
Description
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NatureSynthetic
Specifications
Our Abpromise guarantee covers the use of ab6093 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Blocking
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FormLiquid
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Additional notesStable for one year.
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
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Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2
General Info
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Alternative names
- Acidic (leucine rich) nuclear phosphoprotein 32 family member B
- Acidic leucine rich nuclear phosphoprotein 32 family member B
- Acidic leucine-rich nuclear phosphoprotein 32 family member B
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FunctionMultifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
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Tissue specificityExpressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.
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Sequence similaritiesBelongs to the ANP32 family.
Contains 4 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain. -
DomainHistone binding is mediated by the concave surface of the LRR region.
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Post-translational
modificationsSome glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. -
Cellular localizationNucleus. Accumulates in the nuclei at the S phase and Cytoplasm. Lacks a nuclear localization signal.
- Information by UniProt
References
ab6093 has not yet been referenced specifically in any publications.
