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Rabbit polyclonal to PHD finger protein 6
Predicted to work with:
Mouse, Cow, Pig
Recombinant fragment, corresponding to a region within amino acids 66-251 of Human PHD finger protein 6 (AAH05994).
NT2D1, IMR32, U-87 MG, MCF7 cells and whole cell lysates.
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.01% Thimerosal (merthiolate) Constituents: 78.99% PBS, 1% BSA, 20% Glycerol
Concentration information loading...
Immunogen affinity purified
ab111844 is purified by antigen-affinity chromatography.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 35 kDa.
1/100 - 1/500.
May play a role in transcriptional regulation.
Involvement in disease
Defects in PHF6 are the cause of Boerjeson-Forssman-Lehmann syndrome (BFLS) [MIM:301900]; also known as Boerjeson-Forssman syndrome (BORJ). BFLS is a X-linked recessive disorder characterized by moderate to severe mental retardation, epilepsy, hypogonadism, hypometabolism, obesity with marked gynecomastia, swelling of subcutaneous tissue of the face, narrow palpebral fissure and large but not deformed ears.
Contains 2 PHD-type zinc fingers.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Nucleus. Nucleus > nucleolus. Nuclear, it particularly localizes to the nucleolus.
Information by UniProt
Western blot - Anti-PHD finger protein 6 antibody (ab111844)
Anti-PHD finger protein 6 antibody (ab111844) at 1/1000 dilution + MCF 7 whole cell lysate at 30 µg
Predicted band size: 35 kDa 10% SDS PAGE
Immunocytochemistry/ Immunofluorescence - Anti-PHD finger protein 6 antibody (ab111844)
ab111844 at 1/500 dilution staining PHD finger protein 6 in Paraformaldehyde-fixed MCF7 cells by Immunofluorescence. Lower image shows cells co-stained with Hoechst 33342.
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"