Key features and details
- Irreversible calmodulin antagonist and potent, nonselective, irreversible α-adrenoceptor antagonist
- CAS Number: 63-92-3
- Purity: > 95%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Product namePhenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist
DescriptionIrreversible calmodulin antagonist and potent, nonselective, irreversible α-adrenoceptor antagonist
Biological descriptionIrreversible calmodulin antagonist (IC50 ~ 80 µM) and potent, nonselective, irreversible α-adrenoceptor antagonist (IC50 = 550 nM). Antihypertensive and anti-inflammatory effects in vitro and in vivo. Cell-permeable. Blood-brain barrier impermeable.
Chemical nameN-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144619 has not yet been referenced specifically in any publications.