Overview

  • Product name

    Phentolamine mesylate, alpha-AR antagonist
  • Description

    Potent, competitive and reversible non-selective α-AR antagonist
  • Biological description

    Potent, competitive and reversible non-selective α-adrenoceptor antagonist. Inhibits agonist-induced smooth muscle contractions (IC50 = 5-30 nM). Shows vasodilatory, positive inotropic, chronotropic and antihypertensive effects in vivo.
  • Purity

    > 99%
  • CAS Number

    65-28-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[[(4,5-Dihydro-1H-imidazol-2-ylmethyl)](4-methylphenyl)amino]phenol mesylate
  • Molecular weight

    377.46
  • Molecular formula

    C17H19N3O.CH3SO3H
  • PubChem identifier

    91430
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O.CS(=O)(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lin Q  et al. Effect of chronic restraint stress on human colorectal carcinoma growth in mice. PLoS One 8:e61435 (2013). Read more (PubMed: 23585898) »
  • Pate AT  et al. Neuropeptide W increases mean arterial pressure as a result of behavioral arousal. Am J Physiol Regul Integr Comp Physiol 305:R804-10 (2013). Read more (PubMed: 23926134) »
  • Wang M  et al. Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats. Am J Physiol Regul Integr Comp Physiol 305:R900-7 (2013). Read more (PubMed: 23948775) »
  • Patil PN The classical competitive antagonism of phentolamine on smooth muscle preparations, investigated by two procedures. Auton Autacoid Pharmacol 27:71-7 (2007). Read more (PubMed: 17199878) »

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