Overview

  • Product name

    Phenytoin, Na+ channel blocker
  • Description

    Na+ channel blocker
  • Biological description

    Na+ channel blocker. Reduces Na+ channel availability. Decreases action potential amplitude with minimal effect on frequency. Phenytoin sodium (ab143200) analog. Shows anticonvulsant, antiarrhythmic and muscle relaxant effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    57-41-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5,5-Diphenylimidazolidine-2,4-dione
  • Molecular weight

    252.27
  • Molecular formula

    C15H12N2O2
  • PubChem identifier

    1775
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM (with warming) and in DMSO to 25 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Thomas EA & Petrou S Network-specific mechanisms may explain the paradoxical effects of carbamazepine and phenytoin. Epilepsia 54:1195-202 (2013). Read more (PubMed: 23566163) »
  • Radzicki D  et al. Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures. J Neurosci 33:9920-31 (2013). Read more (PubMed: 23761887) »
  • Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (CAS No. 57-41-0) (Phenytoin) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser 404:1-303 (1993). Read more (PubMed: 12621514) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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