Phenytoin sodium (Dilantin),  multi-channel blocker (ab143200)

Overview

  • Product name

    Phenytoin sodium (Dilantin),  multi-channel blocker
  • Description

    Potent multi-channel blocker
  • Biological description

    Potent multi-channel blocker. Blocks Na+, K+ and Ca 2+ channels. Selectively blocks persistent INaP over shorter INaP actions. Blocks high frequency repetitive firing of action potentials. Shows anticonvulsant effects in vivo. Orally active.
  • Purity

    > 95%
  • CAS Number

    630-93-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5,5-Diphenylhydantoin sodium salt
  • Molecular weight

    274.25
  • Molecular formula

    C15H11N2NaO2
  • PubChem identifier

    657302
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    N1(C(C(N=C1[O-])=O)(C2=CC=CC=C2)C3=CC=CC=C3).[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Colombo E  et al. Phenytoin inhibits the persistent sodium current in neocortical neurons by modifying its inactivation properties. PLoS One 8:e55329 (2013). Read more (PubMed: 23383157) »
  • Erenberk U  et al. Melatonin attenuates phenytoin sodium-induced DNA damage. Drug Chem Toxicol : (2013). Read more (PubMed: 24171672) »
  • Nilsson MF  et al. The effect on rat embryonic heart rate of Na+, K+, and Ca2+ channel blockers, and the human teratogen phenytoin, changes with gestational age. Birth Defects Res B Dev Reprod Toxicol 98:416-27 (2013). Read more (PubMed: 24323366) »

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