Key features and details
- GluA1/GluA2 (formerly GluR1/2) inhibitor
- CAS Number: 401601-12-5
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product namePhilanthotoxin-7,4 (PhTx-74), GluA1/GluA2 (formerly GluR1/2) inhibitor
DescriptionGluA1/GluA2 (formerly GluR1/2) inhibitor
Selective, calcium-permeable AMPA receptor antagonist. Inhibits GluA1/A2 (formerly GluR1/2), with little activity at GluA2/A3 (formerly GluR2/3)
Also available in simple stock solutions (ab146706) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name(S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120257 has been referenced in 1 publication.
- Li XR et al. Acetylation-dependent glutamate receptor GluR signalosome formation for STAT3 activation in both transcriptional and metabolism regulation. Cell Death Discov 7:11 (2021). PubMed: 33446662