Overview

  • Product name

    Phleomycin, Glycopeptide antibiotic
  • Description

    Glycopeptide antibiotic
  • Biological description

    Glycopeptide antibiotic. Intercalates into bacterial DNA inducing double strand breaks and cell death.
  • Purity

    > 97%
  • CAS Number

    11006-33-0
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    1326.38
  • Molecular formula

    C51H75N17O21S2
  • PubChem identifier

    72511
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)(C)OC4C(C(C(C(O4)CO)O)(C(=O)N)O)O)C(=O)NC(C)C(C(C)C(=O)NC(C(=O)C)C(=O)NCCC5=NC(CS5)C6=NC(=CS6)C(=O)N)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hung CY  et al. Gene disruption in Coccidioides using hygromycin or phleomycin resistance markers. Methods Mol Biol 845:131-47 (2012). Read more (PubMed: 22328372) »
  • Wilson JB  et al. Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance. Mutat Res 689:12-20 (2010). Read more (PubMed: 20450923) »
  • Soldati D  et al. Complementation of a Toxoplasma gondii ROP1 knock-out mutant using phleomycin selection. Mol Biochem Parasitol 74:87-97 (1995). Read more (PubMed: 8719248) »

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