Overview

  • Product name

    Phloretin, Dihydrochalcones flavonoid
  • Description

    Dihydrochalcones flavonoid
  • Biological description

    Dihydrochalcones flavonoid. GLUT inhibitor. Active phlorizin (ab143144) metabolite. Blocks L-type Ca2+ channels. Activates Ca2+ -activated K+ channels. Inhibits platelet aggregation. Induces apoptosis. Shows antitumor effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    60-82-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
  • Molecular weight

    274.27
  • Molecular formula

    C15H14O5
  • PubChem identifier

    4788
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=CC(=C(C(=C1)O)C(CCC2=CC=C(C=C2)O)=O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kim MS  et al. Phloretin suppresses thrombin-mediated leukocyte-platelet-endothelial interactions. Mol Nutr Food Res : (2013). Read more (PubMed: 24338998) »
  • Wu CH  et al. In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter. Int J Cancer 124:2210-9 (2009). Read more (PubMed: 19123483) »
  • Crespy V  et al. Bioavailability of phloretin and phloridzin in rats. J Nutr 131:3227-30 (2001). Read more (PubMed: 11739871) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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