Overview

  • Product name

    Phlorizin, SGLT inhibitor
  • Description

    Potent, competitive SGLT inhibitor
  • Biological description

    Potent, competitive SGLT inhibitor (IC50 values are 400 and 65 nM for SGLT1 and SLGT2 respectively). Induces renal glycosuria and blocks intestinal glucose absorption in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    60-81-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[2,4-Dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one
  • Molecular weight

    436.41
  • Molecular formula

    C21H24O10
  • PubChem identifier

    6072
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O
  • Source

    Synthetic

  • Research areas

References

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