Overview

  • Product name
    Anti-Phospholipase C gamma 1 + 2 antibody
  • Description
    Rabbit polyclonal to Phospholipase C gamma 1 + 2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Phospholipase C gamma 1 + 2. It surrounds amino acid 1252 of Phospholipase C gamma 2.
    Database link: P16885

  • Positive control
    • Jurkat whole cell lysate (ab7899), Human brain cortex tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab174787 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 148 kDa.

It should be user determined

Target

  • Relevance
    PLC (Phosphoinositide-specific phospholipase C) plays a significant role in transmembrane signaling. Four members of PLCs have been identified: PLCß, PLCg, PLCd, and PLCe. In response to extracellular stimuli (e.g., hormone, growth factors, neurotransmitters), PLC hydrolizes phosphatidylinositol 4,5-biphosphate (PIP2) into two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PLCg2 is engaged in antigen dependent signaling in B-cells and collagen-dependent signaling in platelets.
  • Cellular localization
    Cytoplasmic and Plasma membrane
  • Database links
  • Alternative names
    • 1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase gamma 1 antibody
    • 1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase gamma 2 antibody
    • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate antibody
    • AI894140 antibody
    • APLAID antibody
    • Cded antibody
    • EC 3.1.4.11 antibody
    • FCAS3 antibody
    • fj46f04 antibody
    • fj57a05 antibody
    • inositoltrisphosphohydrolase antibody
    • MGC38590 antibody
    • monophosphatidylinositol phosphodiesterase antibody
    • NCKAP3 antibody
    • phosphatidylinositol phospholipase C antibody
    • phosphoinositidase C antibody
    • Phosphoinositide phospholipase C antibody
    • phosphoinositide phospholipase C-gamma-1 antibody
    • phosphoinositide phospholipase C-gamma-2 antibody
    • phospholipase C, gamma 1 (formerly subtype 148) antibody
    • phospholipase C, gamma 1 antibody
    • phospholipase C, gamma 2 (phosphatidylinositol-specific) antibody
    • phospholipase C, gamma 2 antibody
    • phospholipase C, phosphatidylinositol-specific antibody
    • phospholipase C-148 antibody
    • phospholipase C-II antibody
    • phospholipase C-IV antibody
    • Plc 1 antibody
    • Plc gamma1 antibody
    • PLC II antibody
    • PLC IV antibody
    • PLC-gamma-2 antibody
    • PLC1 antibody
    • PLC148 antibody
    • Plcg 1 antibody
    • Plcg 2 antibody
    • PLCG1 antibody
    • PLCG2 antibody
    • PLCgamma1 antibody
    • PPLCA antibody
    • triphosphoinositide phosphodiesterase antibody
    • wu:fj46f04 antibody
    • wu:fj57a05 antibody
    see all

Images

  • Anti-Phospholipase C gamma 1 + 2 antibody (ab174787) + Jurkat cell lysate

    Predicted band size: 148 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, cortex, tissue, labeling Phospholipase C gamma 1 + 2 using ab174787 at 5 µg/ml.

References

ab174787 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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