Product namePhosphoramidon, Metallo-endopeptidase inhibitor
Metallo-endopeptidase inhibitor originally derived from cultures of Streptomyces tanashiensis. Inhibits thermolysin, membrane metallo-endopeptidases, and endothelin converting enzyme. Also inhibits NEP 24.11 and NEP2 and weakly inhibits collegenase.
N-(alpha-Rhamnopyranosyloxyphosphinyl)-L-leucyl-L-tryptophan disodium salt
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Isaka D et al. The effects of phosphoramidon on the expression of human endothelin-converting enzyme-1 (ECE-1) isoforms. J Cardiovasc Pharmacol 42:136-41 (2003). Read more (PubMed: 12827039) »
- Matsumaru K et al. Phosphoramidon, an inhibitor of endothelin-converting enzyme, prevents indomethacin-induced gastric mucosal damage in rats. Life Sci 62:PL79-84 (1998). Read more (PubMed: 9472729) »
- Kitagishi K & Hiromi K Binding between thermolysin and its specific inhibitor, phosphoramidon. J Biochem 95:529-34 (1984). Read more (PubMed: 6715312) »