Phosphoramidon, Metallo-endopeptidase inhibitor (ab146309)

Overview

  • Product name

    Phosphoramidon, Metallo-endopeptidase inhibitor
  • Description

    Metallo-endopeptidase inhibitor.
  • Alternative names

    • N-(alpha-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan
  • Biological description

    Metallo-endopeptidase inhibitor originally derived from cultures of Streptomyces tanashiensis. Inhibits thermolysin, membrane metallo-endopeptidases, and endothelin converting enzyme. Also inhibits NEP 24.11 and NEP2 and weakly inhibits collegenase.

  • CAS Number

    119942-99-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(alpha-Rhamnopyranosyloxyphosphinyl)-L-leucyl-L-tryptophan disodium salt

  • Molecular weight

    587.50
  • Molecular formula

    C23H32N3Na2O10P
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Isaka D  et al. The effects of phosphoramidon on the expression of human endothelin-converting enzyme-1 (ECE-1) isoforms. J Cardiovasc Pharmacol 42:136-41 (2003). Read more (PubMed: 12827039) »
  • Matsumaru K  et al. Phosphoramidon, an inhibitor of endothelin-converting enzyme, prevents indomethacin-induced gastric mucosal damage in rats. Life Sci 62:PL79-84 (1998). Read more (PubMed: 9472729) »
  • Kitagishi K & Hiromi K Binding between thermolysin and its specific inhibitor, phosphoramidon. J Biochem 95:529-34 (1984). Read more (PubMed: 6715312) »

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