Overview

  • Product name
  • Description
    Mouse polyclonal to PHOX2A
  • Host species
    Mouse
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Gorilla, Orangutan
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-284 of Human PHOX2A (NP_005160.2).

  • Positive control
    • PHOX2A transfected 293T cell line lysate, HeLa cells
  • General notes
    For IHC and IF applications, antibody purification with Protein A will be needed prior to use.

Properties

Applications

Our Abpromise guarantee covers the use of ab168392 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 30 kDa.
ICC/IF Use a concentration of 10 µg/ml. For IHC and IF applications, antibody purification with Protein A will be needed prior to use.

Target

  • Function
    May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
  • Involvement in disease
    Defects in PHOX2A are the cause of congenital fibrosis of extraocular muscles type 2 (CFEOM2) [MIM:602078]. CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM2 may result from the aberrant development of the oculomotor (nIII), trochlear (nIV) and abducens (nVI) cranial nerve nuclei.
  • Sequence similarities
    Belongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aristaless homeobox (Drosophila) fibrosis of extraocular muscles congenital 2 autosomal recessive antibody
    • Aristaless homeobox gene homolog (Drosophila) antibody
    • Aristaless homeobox homolog antibody
    • Aristaless homeobox protein homolog antibody
    • ARIX 1 homeodomain protein antibody
    • ARIX antibody
    • Arix homeodomain protein antibody
    • ARIX1 homeodomain protein antibody
    • CFEOM 2 antibody
    • CFEOM2 antibody
    • FEOM 2 antibody
    • FEOM2 antibody
    • Fibrosis of extraocular muscles congenital 2 autosomal recessive antibody
    • MGC52227 antibody
    • NCAM 2 antibody
    • NCAM2 antibody
    • Paired like (aristaless) Homeobox 2A antibody
    • Paired like homeobox 2a antibody
    • Paired mesoderm homeobox 2a antibody
    • Paired mesoderm homeobox protein 2A antibody
    • Paired-like homeobox 2A antibody
    • PHOX 2A antibody
    • Phox2 antibody
    • Phox2a antibody
    • PHX2A_HUMAN antibody
    • Pmx 2a antibody
    • Pmx2 antibody
    • Pmx2a antibody
    see all

Images

  • All lanes : Anti-PHOX2A antibody (ab168392) at 1 µg/ml

    Lane 1 : PHOX2A transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Predicted band size: 30 kDa

  • Immunofluorescent analysis of HeLa cells labeling PHOX2A with ab168392 at 10 µg/ml.

References

ab168392 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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