Recombinant
RabMAb

Anti-PHOX2A antibody [EPR9070] (ab134939)

Overview

  • Product name
    Anti-PHOX2A antibody [EPR9070]
    See all PHOX2A primary antibodies
  • Description
    Rabbit monoclonal [EPR9070] to PHOX2A
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: Flow Cyt,ICC/IF or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human PHOX2A aa 50-150. The exact sequence is proprietary.

  • Positive control
    • U87 MG, Neuro 2a, SH SY5Y, HeLa and C6 cell lysates
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab134939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 30 kDa.
IP 1/10 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • Target

    • Function
      May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
    • Involvement in disease
      Defects in PHOX2A are the cause of congenital fibrosis of extraocular muscles type 2 (CFEOM2) [MIM:602078]. CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM2 may result from the aberrant development of the oculomotor (nIII), trochlear (nIV) and abducens (nVI) cranial nerve nuclei.
    • Sequence similarities
      Belongs to the paired homeobox family.
      Contains 1 homeobox DNA-binding domain.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Aristaless homeobox (Drosophila) fibrosis of extraocular muscles congenital 2 autosomal recessive antibody
      • Aristaless homeobox gene homolog (Drosophila) antibody
      • Aristaless homeobox homolog antibody
      • Aristaless homeobox protein homolog antibody
      • ARIX 1 homeodomain protein antibody
      • ARIX antibody
      • Arix homeodomain protein antibody
      • ARIX1 homeodomain protein antibody
      • CFEOM 2 antibody
      • CFEOM2 antibody
      • FEOM 2 antibody
      • FEOM2 antibody
      • Fibrosis of extraocular muscles congenital 2 autosomal recessive antibody
      • MGC52227 antibody
      • NCAM 2 antibody
      • NCAM2 antibody
      • Paired like (aristaless) Homeobox 2A antibody
      • Paired like homeobox 2a antibody
      • Paired mesoderm homeobox 2a antibody
      • Paired mesoderm homeobox protein 2A antibody
      • Paired-like homeobox 2A antibody
      • PHOX 2A antibody
      • Phox2 antibody
      • Phox2a antibody
      • PHX2A_HUMAN antibody
      • Pmx 2a antibody
      • Pmx2 antibody
      • Pmx2a antibody
      see all

    Images

    • All lanes : Anti-PHOX2A antibody [EPR9070] (ab134939) at 1/1000 dilution

      Lane 1 : U-87 MG cell lysate
      Lane 2 : Neuro-2a cell lysate
      Lane 3 : SH-SY5Y cell lysate
      Lane 4 : HeLa cell lysate
      Lane 5 : C6 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Standard HRP labelled goat anti-rabbit at 1/2000 dilution

      Developed using the ECL technique.

      Predicted band size: 30 kDa

    References

    ab134939 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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