RecombinantRabMAb

Recombinant Anti-PHOX2A antibody [EPR9070] (ab134939)

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Western blot - Anti-PHOX2A antibody [EPR9070] (ab134939)
  • Anti-PHOX2A antibody [EPR9070] (ab134939)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR9070] to PHOX2A
  • Suitable for: WB
  • Reacts with: Mouse, Rat, Human

Overview

  • Product name

    Anti-PHOX2A antibody [EPR9070]
    See all PHOX2A primary antibodies

  • Description

    Rabbit monoclonal [EPR9070] to PHOX2A

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF or IHC-P

  • Species reactivity

    Reacts with: Mouse, Rat, Human

  • Immunogen

    Synthetic peptide within Human PHOX2A aa 50-150. The exact sequence is proprietary.

  • Positive control

    • U87 MG, Neuro 2a, SH SY5Y, HeLa and C6 cell lysates

  • General notes

     

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab134939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 30 kDa.
Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 30 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IHC-P.

    • Target

    • Function

      May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.

    • Involvement in disease

      Defects in PHOX2A are the cause of congenital fibrosis of extraocular muscles type 2 (CFEOM2) [MIM:602078]. CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM2 may result from the aberrant development of the oculomotor (nIII), trochlear (nIV) and abducens (nVI) cranial nerve nuclei.

    • Sequence similarities

      Belongs to the paired homeobox family.
      Contains 1 homeobox DNA-binding domain.

    • Cellular localization

      Nucleus.
    • Information by UniProt

    • Database links

      see all

    • Alternative names

      • Aristaless homeobox (Drosophila) fibrosis of extraocular muscles congenital 2 autosomal recessive antibody
      • Aristaless homeobox gene homolog (Drosophila) antibody
      • Aristaless homeobox homolog antibody
      • Aristaless homeobox protein homolog antibody
      • ARIX 1 homeodomain protein antibody
      • ARIX antibody
      • Arix homeodomain protein antibody
      • ARIX1 homeodomain protein antibody
      • CFEOM 2 antibody
      • CFEOM2 antibody
      • FEOM 2 antibody
      • FEOM2 antibody
      • Fibrosis of extraocular muscles congenital 2 autosomal recessive antibody
      • MGC52227 antibody
      • NCAM 2 antibody
      • NCAM2 antibody
      • Paired like (aristaless) Homeobox 2A antibody
      • Paired like homeobox 2a antibody
      • Paired mesoderm homeobox 2a antibody
      • Paired mesoderm homeobox protein 2A antibody
      • Paired-like homeobox 2A antibody
      • PHOX 2A antibody
      • Phox2 antibody
      • Phox2a antibody
      • PHX2A_HUMAN antibody
      • Pmx 2a antibody
      • Pmx2 antibody
      • Pmx2a antibody
      see all

    Images

    • Western blot - Anti-PHOX2A antibody [EPR9070] (ab134939)
      Western blot - Anti-PHOX2A antibody [EPR9070] (ab134939)
      All lanes : Anti-PHOX2A antibody [EPR9070] (ab134939) at 1/1000 dilution

      Lane 1 : U-87 MG cell lysate
      Lane 2 : Neuro-2a cell lysate
      Lane 3 : SH-SY5Y cell lysate
      Lane 4 : HeLa cell lysate
      Lane 5 : C6 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Standard HRP labelled goat anti-rabbit at 1/2000 dilution

      Developed using the ECL technique.

      Predicted band size: 30 kDa

    • Anti-PHOX2A antibody [EPR9070] (ab134939)
      Anti-PHOX2A antibody [EPR9070] (ab134939)

    References (0)

    Publishing research using ab134939? Please let us know so that we can cite the reference in this datasheet.

    ab134939 has not yet been referenced specifically in any publications.

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