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Rabbit monoclonal [EPR9071] to PHOX2A
ICC/IF more details Unsuitable for:
Flow Cyt,IHC-P or IP
Synthetic peptide, coresponding to residues in Human PHOX2A (UniProt: O14813).
SH-SY-5Y and Neuro-2a cell lysates; SH-SY-5Y cells.
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab ® patents
This product is a recombinant rabbit monoclonal antibody.
Shipped at 4°C. Store at -20ºC.
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
Tissue culture supernatant
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/10000. Predicted molecular weight: 30 kDa.
1/100 - 1/250.
Is unsuitable for Flow Cyt,IHC-P or IP.
May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
Involvement in disease
Defects in PHOX2A are the cause of congenital fibrosis of extraocular muscles type 2 (CFEOM2) [MIM:602078]. CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM2 may result from the aberrant development of the oculomotor (nIII), trochlear (nIV) and abducens (nVI) cranial nerve nuclei.
Belongs to the paired homeobox family.
Contains 1 homeobox DNA-binding domain.
Information by UniProt
Aristaless homeobox (Drosophila) fibrosis of extraocular muscles congenital 2 autosomal recessive antibody
Aristaless homeobox gene homolog (Drosophila) antibody
Aristaless homeobox homolog antibody
Immunocytochemistry/ Immunofluorescence - Anti-PHOX2A antibody [EPR9071] (ab155084)
Immunofluorescent analysis of SH-SY-5Y cells, labeling PHOX2A with ab155084 at 1/100 dilution.
Western blot - Anti-PHOX2A antibody [EPR9071] (ab155084)
All lanes : Anti-PHOX2A antibody [EPR9071] (ab155084) at 1/1000 dilution Lane 1 : SH-SY-5Y cell lysate Lane 2 : Neuro-2a cell lysate Lysates/proteins at 10 µg per lane. Secondary All lanes : Goat anti-rabbit HRP at 1/2000 dilution Predicted band size: 30 kDa
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"