Phrixotoxin-1, Specific Kv4.3 and Kv4.2 channel blocker (ab141844)

Overview

  • Product name

    Phrixotoxin-1, Specific Kv4.3 and Kv4.2 channel blocker
  • Description

    Specific Kv4.3 and Kv4.2 channel blocker
  • Biological description

    Potent Kv4.2 and Kv4.3 potassium channel inhibitor (IC50 values are 5 and 28 nM, respectively).
  • Purity

    > 98%
  • CAS Number

    221872-97-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    YCQKWMWTCDSARKCCEGLVCRLWCKKII (Modifications: Ile-29= C-terminal amide; Disulfide bridges: 2-16, 9-21 and 15-25)
  • Molecular weight

    3549.00
  • Molecular formula

    C156H240N44O37S7
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

Images

  • Phrixotoxin-1 inhibits KV4.2 currents expressed in Xenopus oocytes.

    KV4.2 channel currents were recorded using two electrode voltage clamp, with ND 96 in the bath solution. From a holding potential of -100 mV to -10 mV, a 100 ms depolarization was applied every 10 sec in the before (black) or during (green) the application of 100 nM Phrixotoxin-1 (ab141844).

References

This product has been referenced in:

  • Schaarschmidt G  et al. Characterization of voltage-gated potassium channels in human neural progenitor cells. PLoS One 4:e6168 (2009). Read more (PubMed: 19584922) »
  • Chagot B  et al. Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci 13:1197-208 (2004). Read more (PubMed: 15096626) »
  • Diochot S  et al. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol 126:251-63 (1999). Read more (PubMed: 10051143) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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