Overview

  • Product name

    Phrixotoxin-2, Kv4.2 and Kv4.3 channel blocker
  • Description

    Potent, selective and reversible Kv4.2 and Kv4.3 channel blocker
  • Biological description

    Potent, selective Kv4.3 and Kv4.2 potassium channel inhibitor (IC50 values are 71 and 34 nM, respectively). Anticancer activitiy. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    221889-63-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    YCQKWMWTCDEERKCCEGLVCRLWCKRIINM (Modifications: Met-31= C-terminal amide; Disulfide bridges: 2-16, 9-21 and 15-25)
  • Molecular weight

    3923.00
  • Molecular formula

    C169H259N49O43S8
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

Images

  • Phrixotoxin-2 inhibits KV4.3 currents expressed in Xenopus oocytes.

    Expressed KV4.3 currents were recorded using two electrode voltage clamp with ND 96 in the bath solution. Left: Traces of current response to 100 ms depolarization from a holding potential of -100 mV to -10 mV, applied every 10 sec before, during and after wash of Phrixotoxin-2 (ab141843) at the indicated concentrations. Middle: Mean and S.D. dose response curve for 3 experiments. Right: Mean and S.D. voltage dependence of the percentage inhibition caused by 1 µM Phrixotoxin-2 (n = 3).

References

This product has been referenced in:

  • Chan DC  et al. Exisulind in combination with docetaxel inhibits growth and metastasis of human lung cancer and prolongs survival in athymic nude rats with orthotopic lung tumors. Clin Cancer Res 8:904-12 (2002). Read more (PubMed: 11895925) »
  • Marchettini P  et al. Docetaxel: pharmacokinetics and tissue levels after intraperitoneal and intravenous administration in a rat model. Cancer Chemother Pharmacol 49:499-503 (2002). Read more (PubMed: 12107555) »
  • Diochot S  et al. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol 126:251-63 (1999). Read more (PubMed: 10051143) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141843.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up