Key features and details
- Voltage-gated Na+ channel blocker
- CAS Number:
- Purity: > 99%
- Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
- Form / State: Solid
- Source: Synthetic
Product namePhrixotoxin-3, Voltage-gated Na+ channel blocker
DescriptionVoltage-gated Na+ channel blocker
SequenceDCLGFLWKCNPSNDKCCRPNLVCSRKDKWCKYQI (Modifications: Disulfide bonds: 2-17, 9-23, 16-30)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewAny aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab141845, Phrixotoxin-3, Voltage-gated Na+ channel blocker
Phrixotoxin-3 inhibits NaV1.2 channels heterologously expressed in Xenopus oocytes.
Superimposed traces of NaV1.2 currents before (green) and during (black) application of 300 nM Phrixotoxin-3 (ab141845). Currents were elicited from a holding potential of -100 mV and test pulses of 35 ms to +60 mV were delivered every 5 sec.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141845 has not yet been referenced specifically in any publications.