Overview

  • Product name

    PHTPP, ERbeta antagonist
  • Description

    Selective ERβ antagonist
  • Biological description

    Selective ERβ antagonist. Enhances cell growth. Impairs Nrf2 activation. Shows antiestrogenic effects in vivo.
  • Purity

    > 99%
  • CAS Number

    805239-56-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
  • Molecular weight

    423.31
  • Molecular formula

    C20H11F6N3O
  • PubChem identifier

    11201035
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Chan KK  et al. Targeting estrogen receptor subtypes (ERa and ERß) with selective ER modulators in ovarian cancer. J Endocrinol 221:325-36 (2014). Read more (PubMed: 24819599) »
  • Litwa E  et al. Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling. J Steroid Biochem Mol Biol 144PB:334-347 (2014). Read more (PubMed: 25092517) »
  • Grassi D  et al. Role of oestrogen receptors on the modulation of NADPH-diaphorase-positive cell number in supraoptic and paraventricular nuclei of ovariectomised female rats. J Neuroendocrinol 25:244-50 (2013). Read more (PubMed: 22967140) »
See all 2 Publications for this product

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