Key features and details
- Rabbit polyclonal to PHYH
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PHYH antibody
DescriptionRabbit polyclonal to PHYH
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Recombinant fragment, corresponding to amino acids 34-321 of Human PHYH (BC029512).
- Human fetal kidney and liver lysates; Human breast carcinoma tissue
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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FormLyophilized:Reconstitute in 200µl sterile water
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Our Abpromise guarantee covers the use of ab118195 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 39 kDa.|
|IHC-P||1/100 - 1/500.|
FunctionConverts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
Tissue specificityExpressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung and skeletal muscle.
PathwayLipid metabolism; fatty acid metabolism.
Involvement in diseaseDefects in PHYH are a cause of Refsum disease (RD) [MIM:266500]. RD is an autosomal recessive disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentosa, peripheral neuropathy, cerebellar ataxia, and elevated protein levels in the cerebrospinal fluid (CSF). Patients exhibit accumulation of the branched-chain fatty acid, phytanic acid, in blood and tissues. Less constant features are nerve deafness, anosmia, skeletal abnormalities, ichthyosis, cataracts and cardiac impairment. Manifestations of the disease appear in the second or third decade of life.
Sequence similaritiesBelongs to the PhyH family.
- Information by UniProt
- LN1 antibody
- LNAP1 antibody
- LNAP1, mouse, homolog of antibody
All lanes : Anti-PHYH antibody (ab118195) at 1/500 dilution
Lane 1 : Human fetal kidney lysate
Lane 2 : Human fetal liver lysate
Predicted band size: 39 kDa
ab118195, at 1/100 dilution, staining PHYH in formalin-fixed, paraffin-embedded Human breast carcinoma tissue showing cytoplasmic staining, by Immunohistochemistry.
ab118195 has not yet been referenced specifically in any publications.