Recombinant
RabMAb

Recombinant Anti-PI 3 Kinase catalytic subunit alpha/PIK3CA antibody [SP139], prediluted (ab135371)

Overview

  • Product name

    Anti-PI 3 Kinase catalytic subunit alpha/PIK3CA antibody [SP139], prediluted
    See all PI 3 Kinase catalytic subunit alpha/PIK3CA primary antibodies
  • Description

    Rabbit monoclonal [SP139] to PI 3 Kinase catalytic subunit alpha/PIK3CA, prediluted
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Chicken, Cow
  • Immunogen

    Synthetic peptide within Human PI 3 Kinase catalytic subunit alpha/PIK3CA aa 500-600 (internal sequence). The exact sequence is proprietary.
    Database link: P42336

  • Positive control

    • Human breast carcinoma tissue
  • General notes

     

     

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab135371 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1. Antigen Retrieval: Boil tissue section in 1mM EDTA buffer, pH 8.0 for 10 min followed by cooling at room temperature for 20 min.

Target

  • Function

    Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
  • Involvement in disease

    Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500].
    Defects in PIK3CA are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
    Defects in PIK3CA are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
    Defects in PIK3CA may underlie hepatocellular carcinoma (HCC) [MIM:114550].
    Defects in PIK3CA are a cause of keratosis seborrheic (KERSEB) [MIM:182000]. A common benign skin tumor. Seborrheic keratoses usually begin with the appearance of one or more sharply defined, light brown, flat macules. The lesions may be sparse or numerous. As they initially grow, they develop a velvety to finely verrucous surface, followed by an uneven warty surface with multiple plugged follicles and a dull or lackluster appearance.
  • Sequence similarities

    Belongs to the PI3/PI4-kinase family.
    Contains 1 C2 domain.
    Contains 1 PI3K/PI4K domain.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha antibody
    • 5-bisphosphate 3-kinase catalytic subunit alpha isoform antibody
    • caPI3K antibody
    • CLOVE antibody
    • CWS5 antibody
    • MCAP antibody
    • MCM antibody
    • MCMTC antibody
    • MGC142161 antibody
    • MGC142163 antibody
    • p110 alpha antibody
    • p110alpha antibody
    • Phosphatidylinositol 3 kinase catalytic alpha polypeptide antibody
    • Phosphatidylinositol 3 kinase catalytic 110 KD alpha antibody
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha antibody
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform antibody
    • Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha antibody
    • Phosphatidylinositol-4 antibody
    • Phosphoinositide 3 kinase catalytic alpha polypeptide antibody
    • PI 3 Kinase catalytic subunit alpha antibody
    • PI3 kinase p110 subunit alpha antibody
    • PI3-kinase subunit alpha antibody
    • PI3K antibody
    • PI3K-alpha antibody
    • PI3KC A antibody
    • PIK3C A antibody
    • Pik3ca antibody
    • PK3CA antibody
    • PK3CA_HUMAN antibody
    • PtdIns 3 kinase p110 antibody
    • PtdIns-3-kinase subunit alpha antibody
    • PtdIns-3-kinase subunit p110-alpha antibody
    • Serine/threonine protein kinase PIK3CA antibody
    see all

Images

  • Immunohistochemical analysis of paraffin embedded Human breast carcinoma tissue labelling PI 3 Kinase catalytic subunit alpha/PIK3CA with ab135371.

References

This product has been referenced in:

  • Ma M  et al. Preeclampsia is associated with hypermethylation of IGF-1 promoter mediated by DNMT1. Am J Transl Res 10:16-39 (2018). Read more (PubMed: 29422991) »
See 1 Publication for this product

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