Overview

  • Product name

    Picoplatin, antineoplastic agent
  • Description

    Platinum based antineoplastic agent
  • Biological description

    Third generation platinum designed to overcome platinum resistance. Induces apoptosis in vitro. Antitumor agent, displays a spectrum of antineoplastic activity including inhibition of DNA replication and transcription, and the induction of apoptosis. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    181630-15-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Azane 2-methylpyridine platinum(II) dichloride
  • Molecular weight

    376.15
  • Molecular formula

    C6H10Cl2N2Pt
  • PubChem identifier

    177358
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC=CC=N1.N.[Cl-].[Cl-].[Pt+2]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tang CH  et al. Picoplatin overcomes resistance to cell toxicity in small-cell lung cancer cells previously treated with cisplatin and carboplatin. Cancer Chemother Pharmacol 67:1389-400 (2011). Read more (PubMed: 20809122) »
  • More SS  et al. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Mol Cancer Ther 9:1058-69 (2010). Read more (PubMed: 20371711) »
  • Margiotta N  et al. Platinum(II) complexes with bioactive carrier ligands having high affinity for the translocator protein. J Med Chem 53:5144-54 (2010). Read more (PubMed: 20568783) »

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