Picotamide, Thromboxane A2 antagonist and TXA2 synthase inhibitor (ab145239)

Overview

  • Product name

    Picotamide, Thromboxane A2 antagonist and TXA2 synthase inhibitor
  • Description

    Dual activity thromboxane A2 antagonist and TXA2 synthase inhibitor
  • Biological description

    Dual activity thromboxane A2 antagonist and TXA2 synthase inhibitor. Inhibits platelet aggregation. Shows smooth muscle relaxant effects. Shows antithrombotic and anti-ischemic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    32828-81-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide
  • Molecular weight

    376.41
  • Molecular formula

    C21H20N4O3
  • PubChem identifier

    4814
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=C(C=C(C=C1)C(=O)NCC2=CN=CC=C2)C(=O)NCC3=CN=CC=C3
  • Source

    Synthetic

References

This product has been referenced in:

  • Hennenberg M  et al. The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle. Am J Physiol Renal Physiol 305:F1383-90 (2013). Read more (PubMed: 24049147) »
  • Vezza R  et al. Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism. Thromb Haemost 78:1385-91 (1997). Read more (PubMed: 9408024) »
  • Gresele P  et al. Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression. Thromb Haemost 64:80-6 (1990). Read more (PubMed: 2274931) »

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