Anti-PICP antibody [8] (ab17202)

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Overview

  • Product name
    Anti-PICP antibody [8]
    See all PICP primary antibodies
  • Description
    Mouse monoclonal [8] to PICP
  • Host species
    Mouse
  • Specificity
    ab17202 is specific for native PICP from amniotic fluid.
  • Tested applications
    Suitable for: IP, ELISA, Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    PICP purified from second trimester amniotic fluid by affinity chromatography.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    pH: 7.40
    Preservative: 0.097% Sodium azide
    Constituents: 0.0268% PBS, 2.9% Sodium chloride
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Monoclonal
  • Clone number
    8
  • Isotype
    IgG1
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab17202 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent concentration.
ELISA 1/6000.
Sandwich ELISA Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Mouse monoclonal [002-18] to PICP (ab76102). Use as Capture antibody with recommended pair.

Target

  • Function
    Type I collagen is a member of group I collagen (fibrillar forming collagen).
  • Tissue specificity
    Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
  • Involvement in disease
    Caffey disease
    Ehlers-Danlos syndrome 1
    Ehlers-Danlos syndrome 7A
    Osteogenesis imperfecta 1
    Osteogenesis imperfecta 2
    Osteogenesis imperfecta 3
    Osteogenesis imperfecta 4
    Osteoporosis
    A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF.
  • Sequence similarities
    Belongs to the fibrillar collagen family.
    Contains 1 fibrillar collagen NC1 domain.
    Contains 1 VWFC domain.
  • Domain
    The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
  • Post-translational
    modifications
    Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains.
    O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
    • Alternative names
      • COL1A1 antibody
      • Alpha 1 type I collagen antibody
      • Alpha-1 type I collagen antibody
      • CO1A1_HUMAN antibody
      • COL1A1 antibody
      • Collagen alpha-1(I) chain antibody
      • Collagen type I alpha 1 antibody
      • Procollagen type I C terminal propeptide antibody
      see all

    References

    ab17202 has not yet been referenced specifically in any publications.

    Publishing research using ab17202? Please let us know so that we can cite the reference in this datasheet.

    Customer reviews and Q&As

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    Question

    I’m interested in testing one of your procollagen 1 C-terminal peptide (PICP) antibodies (particularly Ab17202) for the immunoprecipitation of PICP from serum. I’m wondering if I can take part in your antibody discount testing program.

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    Answer

    Thank you for contacting us. Below is the information about our testing discount program. If you will be working in IP, you may also be interested in our new range of VeriBlot secondary antibodies that are specific for native IgGs. With these secondaries, you can eliminate bands from the heavy and light chains of the IP antibody when analyzing by WB. https://www.abcam.com/veriblot


    DISCOUNT CODE: 10***
    Expiration date: November 27th, 2012

    I am very pleased to hear you would like to accept our offer and test ab17202 in IP. This code will give you: 1 free primary antibody before the expiration date. To redeem this offer, please submit an Abreview forIP and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. Please remember that submission of the Abreview is sufficient for the discount code to become active.
    For more information on how to submit an Abreview, please visit the site: https://www.abcam.com/Abreviews.

    Remember, we publish both positive and negative Abreviews on our datasheets so please submit the results of your tests. The code will be active once the Abreview has been submitted and can be redeemed in one of the following ways: 1) Call to place your order and mention the code to our customer service department; 2) Include the code in your fax order; 3) Place your order on the web and enter the promotional code.

    Any feedback that you can provide will be greatly appreciated, whether positive or negative. If you have any further questions, please do not hesitate to contact us. We look forward to receiving your Abreview and wish you luck with your research.

    The terms and conditions applicable to this offer can be found here: www.abcam.com/collaborationdiscount.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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