Key features and details
- GABAA antagonist
- CAS Number: 124-87-8
- Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating)
- Form / State: Solid
- Source: Anamirta cocculus
Product namePicrotoxin, GABAA antagonist
Plant alkaloid. Non-competitive GABAA antagonist. Also inhibits homomeric glycine receptor. Convulsant in vivo.
5g pack supplied as 5x1g
Chemical name1:1 mixture of picrotoxinin and picrotin
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 50 mM (with heating)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120315 has been referenced in 57 publications.
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- Weyrer C et al. The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation. Cell Rep 26:2289-2297.e3 (2019). PubMed: 30811980