Overview

  • Product name

  • Description

    Rabbit polyclonal to PIF1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human PIF1 aa 125-360.
    Database link: Q9H611

  • Positive control

    • IHC-P: Human gastric cancer and breast cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab222906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
  • Tissue specificity

    Weak ubiquitous expression.
  • Sequence similarities

    Belongs to the helicase family. PIF1 subfamily.
  • Cellular localization

    Mitochondrion and Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • ATP dependent DNA helicase PIF1 antibody
    • ATP-dependent DNA helicase PIF1 antibody
    • C15orf20 antibody
    • DNA helicase homolog PIF1 antibody
    • DNA helicase PIF1 antibody
    • DNA repair and recombination helicase PIF1 antibody
    • Petite integration frequency 1 antibody
    • PIF antibody
    • PIF1 5' to 3' DNA helicase antibody
    • PIF1 5' to 3' DNA helicase homolog antibody
    • PIF1 antibody
    • PIF1 DNA helicase antibody
    • PIF1/RRM3 DNA helicase like protein antibody
    • PIF1/RRM3 DNA helicase-like protein antibody
    • PIF1_HUMAN antibody
    see all

Images

  • Paraffin embedded human gastric cancer tissue stained for PIF1 with ab222906 (1/100 dilution) in immunohistochemical analysis.

  • Paraffin embedded human breast cancer tissue stained for PIF1 with ab222906 (1/100 dilution) in immunohistochemical analysis.

References

ab222906 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab222906.
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