Key features and details
- Inhibitor of p53-mediated apoptosis
- CAS Number: 64984-31-2
- Purity: > 98%
- Soluble in ethanol to 75 mM and in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Product namePifithrin-mu, Inhibitor of p53-mediated apoptosis
DescriptionInhibitor of p53-mediated apoptosis
- Antigen NY-CO-13
- Cellular tumor antigen p53
Biological descriptionAn inhibitor of p53-mediated apoptosis. Prevents p53 binding at the mitochondrial surface without affecting p53 transactivational activities. Pifithrin-μ reduces p53-mediated apoptosis triggered by nutlin; also interacts selectively with HSP70, disrupting its association with many substrate proteins.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 75 mM and in DMSO to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120886 has not yet been referenced specifically in any publications.