Key features and details
- Rabbit polyclonal to PILRA
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PILRA antibody
DescriptionRabbit polyclonal to PILRA
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
- Human tonsil tissue.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab220673 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionPaired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Tissue specificityPredominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors.
Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain.
DomainContains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. PTPN6 seems to bind predominantly to the first ITIM motif.
modificationsAccording to PubMed:10660620, N- and O-glycosylated. According to PubMed:10903717, only N-glycosylated.
Phosphorylated on tyrosine residues.
Cellular localizationSecreted and Cell membrane.
- Information by UniProt
- Cell surface receptor FDF03 antibody
- FDF03 antibody
- Inhibitory receptor PILR-alpha antibody
ab220673 has not yet been referenced specifically in any publications.