Key features and details
- Rabbit polyclonal to PIM1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PIM1 antibody
See all PIM1 primary antibodies
DescriptionRabbit polyclonal to PIM1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Cow, Cat
Synthetic peptide within Human PIM1 aa 250-313. The exact sequence is proprietary.
Database link: P11309
- WB: K562 whole cell lysate.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituent: Tris citrate/phosphate
pH 7 to 8
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab245417 was affinity purified using an epitope specific to PIM1 immobilized on solid support.
Our Abpromise guarantee covers the use of ab245417 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/5000 - 1/15000. Predicted molecular weight: 36 kDa.|
FunctionMay affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Isoform 2 promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B. Isoform 2 also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3. Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provides a selective advantage in tumorigenesis.
Tissue specificityExpressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.
Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Contains 1 protein kinase domain.
modificationsAutophosphorylated on both serine/threonine and tyrosine residues.
Cellular localizationCytoplasm. Nucleus and Cell membrane.
- Information by UniProt
- Oncogene PIM 1 antibody
- Oncogene PIM1 antibody
- PIM 1 antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab245417 has not yet been referenced specifically in any publications.