Pimaric acid (PiMA), KCa1.1 (large conductance Ca2+ activated K+ (BK)) channel activator (ab141837)

Overview

  • Product name

    Pimaric acid (PiMA), KCa1.1 (large conductance Ca2+ activated K+ (BK)) channel activator
  • Description

    Potent KCa1.1 (large conductance Ca2+ activated K+ (BK)) channel activator
  • Biological description

    Potent KCa1.1 (large conductance Ca2+ activated K+ (BK)) channel activator. Increases Ca2+ and voltage-sensitivity of BKα-subunit in vitro.
  • Purity

    > 85%
  • CAS Number

    127-27-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R,4aS,4bR,7R,10aS)-7-Ethenyl-1,4a,7-trimethyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid
  • Molecular weight

    302.00
  • Molecular formula

    C20H30O2
  • PubChem identifier

    10116
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1(CCC2C(=C1)CCC3C2(CCCC3(C)C(=O)O)C)C=C
  • Research areas

References

This product has been referenced in:

  • Ali F  et al. 4-epi-Pimaric acid: a phytomolecule as a potent antibacterial and anti-biofilm agent for oral cavity pathogens. Eur J Clin Microbiol Infect Dis 31:149-59 (2012). Read more (PubMed: 21594714) »
  • Suh SJ  et al. Pimaric acid from Aralia cordata has an inhibitory effect on TNF-a-induced MMP-9 production and HASMC migration via down-regulated NF-?B and AP-1. Chem Biol Interact 199:112-9 (2012). Read more (PubMed: 22705379) »
  • Imaizumi Y  et al. Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. Mol Pharmacol 62:836-46 (2002). Read more (PubMed: 12237330) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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