Pimasertib (AS-703026), MEK1/2 inhibitor (ab235569)

Overview

  • Product name

    Pimasertib (AS-703026), MEK1/2 inhibitor
  • Description

    Selective and potent ATP non-competitive allosteric inhibitor of MEK1/2.
  • Alternative names

    • AS-703026
  • Purity

    > 98%
  • CAS Number

    1236699-92-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide

  • Molecular weight

    431.20
  • Molecular formula

    C15H15FlN3O3
  • PubChem identifier

    44187362
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    DMSO 86 mg/mL (199.44 mM)

    Insoluble in water and ethanol

  • SMILES

    C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NCC(CO)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Lu H  et al. Structure-based design and synthesis of bicyclic fused-pyridines as MEK inhibitors. Bioorg Med Chem Lett 24:2555-9 (2014). Read more (PubMed: 24755426) »
  • Martinelli E  et al. Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells. Int J Cancer 133:2089-101 (2013). Read more (PubMed: 23629727) »
  • Kim K  et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol 149:537-49 (2010). Read more (PubMed: 20331454) »

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