Anti-PINX1/LPTS antibody (ab217960)
Key features and details
- Rabbit polyclonal to PINX1/LPTS
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-PINX1/LPTS antibody
See all PINX1/LPTS primary antibodies -
Description
Rabbit polyclonal to PINX1/LPTS -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Human -
Immunogen
Synthetic peptide within Human PINX1/LPTS aa 50-150 conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: Q96BK5 -
Positive control
- IHC-P; Mouse kidney tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 48.98% TBS, 1X -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab217960 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/100 - 1/500.
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Notes |
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IHC-P
1/100 - 1/500. |
Target
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Function
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. -
Tissue specificity
Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines. -
Sequence similarities
Belongs to the PINX1 family.
Contains 1 G-patch domain. -
Domain
The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.
The TBM domain mediates interaction with TERF1. -
Cellular localization
Nucleus. Nucleus > nucleolus. Chromosome > telomere. Chromosome > centromere > kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE. - Information by UniProt
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Database links
- Entrez Gene: 54984 Human
- Entrez Gene: 72400 Mouse
- Entrez Gene: 305963 Rat
- Omim: 606505 Human
- SwissProt: Q96BK5 Human
- SwissProt: Q9CZX5 Mouse
- SwissProt: A4L691 Rat
- Unigene: 490991 Human
see all -
Alternative names
- 67-11-3 protein antibody
- FLJ20565 antibody
- Hepatocellular carcinoma-related putative tumor suppressor antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab217960 has not yet been referenced specifically in any publications.