Overview

  • Product name

    Pioglitazone (Actos), PPARgamma agonist
  • Description

    Selective PPARγ agonist
  • Biological description

    Selective PPARγ agonist (EC50 values are 0.6 and 10 μM for PPARγ and PPARα respectively). Thiazolidinedione derivative. Shows antidiabetic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    111025-46-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sears DD  et al. Selective modulation of promoter recruitment and transcriptional activity of PPARgamma. Biochem Biophys Res Commun 364:515-21 (2007). Read more (PubMed: 17963725) »
  • Momose Y  et al. Novel 5-substituted-1H-tetrazole derivatives as potent glucose and lipid lowering agents. Chem Pharm Bull (Tokyo) 50:100-11 (2002). Read more (PubMed: 11824568) »
  • Arakawa K  et al. Actions of novel antidiabetic thiazolidinedione, T-174, in animal models of non-insulin-dependent diabetes mellitus (NIDDM) and in cultured muscle cells. Br J Pharmacol 125:429-36 (1998). Read more (PubMed: 9806323) »

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