• Product name
  • Description
    Rabbit polyclonal to PION
  • Host species
  • Specificity
    ab106630 is predicted to not cross-react with other F-box protein family members.
  • Tested applications
    Suitable for: IHC-P, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human PION (C terminal).

  • Positive control
    • EL4 cell lysate.


  • Form
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab106630 was purified by affinity chromatography via a peptide column.
  • Clonality
  • Isotype


Our Abpromise guarantee covers the use of ab106630 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.25 µg/ml. Predicted molecular weight: 98 kDa.


  • Function
    Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Belongs to the GSAP family.
  • Post-translational
    The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form.
  • Cellular localization
    Golgi apparatus > trans-Golgi network.
  • Information by UniProt
  • Database links
  • Alternative names
    • A530088I07Rik antibody
    • DKFZp667B242 antibody
    • Gamma-secretase-activating protein 16 kDa C-terminal form antibody
    • GSAP antibody
    • GSAP-16K antibody
    • GSAP_HUMAN antibody
    • MGC126548 antibody
    • Pigeon homolog (Drosophila) antibody
    • Pion antibody
    • Protein pigeon homolog antibody
    • tcag7.1314 antibody
    see all


  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of mouse brain tissue staining PION with ab106630 at 20µg/ml
  • Immunohistochemistry (Formalin-fixed paraffin embedded sections) of mouse brain tissue labeling PION with Anti-PION antibody (ab106630) at 5μg/ml.
  • All lanes : Anti-PION antibody (ab106630) at 0.25 µg/ml

    Lane 1 : EL4 cell lysate
    Lane 2 : EL4 cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 98 kDa

  • Immunofluorescence of PION in Human Brain cells using ab106630 at 20 ug/ml.


ab106630 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for your phone call. Yes, ab106630 will detect the 16 kDa active form of PION as long as it is expressed at detectable levels in your samples. I hope this helps, please let me know if you need any additional information.

Thank you for your patience. I just heard back from the lab with the following good news: There is 100% homology between the immunogen for catalog number ab106630 and the sequence provided. I hope this information is helpful to yo...

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Thank you for contacting us. Unfortunately, the exact immunogen sequence is proprietary and we are not able to disclose it. However, if you please could send me the sequence of the 16 kDa C-terminal fragment of PION that you would like ...

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