• Product name

  • Description

    Rabbit polyclonal to PIP5K1C
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Chicken, Cow
  • Immunogen

    Recombinant fragment within Human PIP5K1C (internal sequence). The exact sequence is proprietary.
    Database link: O60331

  • Positive control

    • WB: A431, NCI-H1299 and HeLa S3 whole cell lysates; Mouse brain lysate.
  • General notes

     This product was previously labelled as PIP5KI gamma



  • Form

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab228620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 73 kDa.


  • Function

    Plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
  • Involvement in disease

    Defects in PIP5K1C are the cause of lethal congenital contracture syndrome type 3 (LCCS3) [MIM:611369]; also known as multiple contractural syndrome Israeli Bedouin type B. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, the Pena-Shokeir phenotype, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS3 patients present at birth with severe multiple joint contractures with severe muscle wasting and atrophy, mainly in the legs. LCCS3 can be distinguished from the original LCCS by the absence of hydrops, fractures, and multiple pterygia.
  • Sequence similarities

    Contains 1 PIPK domain.
  • Cellular localization

    Cell membrane. Cytoplasmic, associated with the plasma membrane. Detected in focal adhesion plaques, membrane ruffles and plasma membrane invaginations.
  • Information by UniProt
  • Database links

  • Alternative names

    • Diphosphoinositide kinase antibody
    • LCCS3 antibody
    • Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody
    • Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma antibody
    • PI51C antibody
    • PI51C_HUMAN antibody
    • PIP5K GAMMA antibody
    • PIP5K1-gamma antibody
    • Pip5k1c antibody
    • PIP5KIgamma antibody
    • PtdIns(4)P 5 kinase gamma antibody
    • PtdIns(4)P-5-kinase 1 gamma antibody
    • Type I PIP kinase antibody
    see all


  • Anti-PIP5K1C antibody (ab228620) at 1/1000 dilution + Mouse brain lysate at 50 µg

    Predicted band size: 73 kDa

    7.5% SDS-PAGE gel.

  • All lanes : Anti-PIP5K1C antibody (ab228620) at 1/500 dilution

    Lane 1 : A431 (human epidermoid carcinoma cell line) whole cell lysate
    Lane 2 : NCI-H1299 (human lung carcinoma cell line) whole cell lysate
    Lane 3 : HeLa S3 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 73 kDa

    7.5% SDS-PAGE gel.


ab228620 has not yet been referenced specifically in any publications.

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