Overview

  • Product name

    Piperine, TRPV1 agonist
  • Description

    TRPV1 agonist
  • Biological description

    TRPV1 agonist (EC50 = 38 μM). Non-selective GABAA agonist (EC50 = 60 μM). Shows neuroprotective, anti-inflammatory, and antioxidant effects in vivo.
  • Purity

    > 95%
  • CAS Number

    94-62-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2E,4E)-5-(1,3-Benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
  • Molecular weight

    285.34
  • Molecular formula

    C17H19NO3
  • PubChem identifier

    638024
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Matsushita A  et al. Inhibition by TRPA1 agonists of compound action potentials in the frog sciatic nerve. Biochem Biophys Res Commun 434:179-84 (2013). Read more (PubMed: 23537660) »
  • Khom S  et al. GABAA receptor modulation by piperine and a non-TRPV1 activating derivative. Biochem Pharmacol 85:1827-36 (2013). Read more (PubMed: 23623790) »
  • Rinwa P & Kumar A Piperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice. Brain Res 1488:38-50 (2012). Read more (PubMed: 23099054) »
  • McNamara FN  et al. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 144:781-90 (2005). Read more (PubMed: 15685214) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142933.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up