Piracetam, positive allosteric modulator of AMPA receptors (ab141380)

Overview

  • Product name

    Piracetam, positive allosteric modulator of AMPA receptors
  • Description

    Nootropic; positive allosteric modulator at AMPA receptors
  • Biological description

    Positive allosteric modulator at AMPA receptors. Nootropic agent and GABA (ab120359) derivative. Potentiates cholinergic and glutamatergic neurotransmission via modulation of ion flux. Variety of biological effects including neuroprotection, anticonvulsant properties and reduced vascular endothelium adhesion. Active in vivo.

    Also available in simple stock solutions (ab146734) - add 1 ml of water to get an exact, ready-to-use concentration.
  • CAS Number

    7491-74-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Oxo-1-pyrrolidineacetamide
  • Molecular weight

    142.16
  • Molecular formula

    C6H10N2O2
  • PubChem identifier

    4843
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C1CCCN1CC(=O)N
  • Source

    Synthetic

References

This product has been referenced in:

  • Ahmed AH & Oswald RE Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. J Med Chem 53:2197-203 (2010). Read more (PubMed: 20163115) »
  • Winblad B Piracetam: a review of pharmacological properties and clinical uses. CNS Drug Rev 11:169-82 (2005). Read more (PubMed: 16007238) »
  • Vernon MW & Sorkin EM Piracetam. An overview of its pharmacological properties and a review of its therapeutic use in senile cognitive disorders. Drugs Aging 1:17-35 (1991). Read more (PubMed: 1794001) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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