Pirenzepine dihydrochloride, M1 antagonist (ab120153)
Key features and details
- M1 antagonist
- CAS Number: 29868-97-1
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Pirenzepine dihydrochloride, M1 antagonist -
Description
M1 antagonist -
Biological description
Selective M1 receptor antagonist.
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CAS Number
29868-97-1 -
Chemical structure
Properties
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Chemical name
5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride -
Molecular weight
424.32 -
Molecular formula
C19H21N5O2.2HCl -
PubChem identifier
71405 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.O=C(CN1CCN(C)CC1)N4c2ccccc2C(=O)Nc3cccnc34 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (4)
ab120153 has been referenced in 4 publications.
- Hu NW et al. mGlu5 receptors and cellular prion protein mediate amyloid-ß-facilitated synaptic long-term depression in vivo. Nat Commun 5:3374 (2014). PubMed: 24594908
- Barrett SG & Chapman CA Contribution of muscarinic M1 receptors to the cholinergic suppression of synaptic responses in layer II of the entorhinal cortex. Neurosci Lett 554:11-5 (2013). PubMed: 24012918
- Glasgow SD et al. Cholinergic suppression of excitatory synaptic transmission in layers II/III of the parasubiculum. Neuroscience 201:1-11 (2012). PubMed: 22138154
- Gorini C et al. Endogenous inhibition of the trigeminally evoked neurotransmission to cardiac vagal neurons by muscarinic acetylcholine receptors. J Neurophysiol 104:1841-8 (2010). PubMed: 20719927