Overview

  • Product name

    Anti-Pirin/PIR antibody [EPR11375(B)]
    See all Pirin/PIR primary antibodies
  • Description

    Rabbit monoclonal [EPR11375(B)] to Pirin/PIR
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    corresponding to Human Pirin/PIR.
    Database link: O00625

  • Positive control

    • MCF7, HeLa, A431 and A375 cell lysates.
  • General notes

     

     

    Previously labelled as Pirin.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab157212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 32 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function

      Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).
    • Tissue specificity

      Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.
    • Pathway

      Flavonoid metabolism; quercetin degradation.
    • Sequence similarities

      Belongs to the pirin family.
    • Cellular localization

      Nucleus. Cytoplasm. Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.
    • Information by UniProt
    • Database links

    • Alternative names

      • 3-dioxygenase PIR antibody
      • Iron binding nuclear protein antibody
      • Pir antibody
      • PIR_HUMAN antibody
      • Pirin antibody
      • Probable quercetin 2 antibody
      • probable quercetin 2,3-dioxygenase PIR antibody
      • Probable quercetinase antibody
      see all

    Images

    • All lanes : Anti-Pirin/PIR antibody [EPR11375(B)] (ab157212) at 1/1000 dilution

      Lane 1 : MCF-7 cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : A431 cell lysate
      Lane 4 : A375 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 32 kDa

    References

    ab157212 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab157212.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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