Key features and details
- Rabbit monoclonal [EPR11376] to Pirin/PIR - BSA and Azide free
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
Product nameAnti-Pirin/PIR antibody [EPR11376] - BSA and Azide free
See all Pirin/PIR primary antibodies
DescriptionRabbit monoclonal [EPR11376] to Pirin/PIR - BSA and Azide free
Tested applicationsSuitable for: WBmore details
Unsuitable for: Flow Cyt,ICC,IHC-P or IP
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide within Human Pirin/PIR aa 200 to the C-terminus (Cysteine residue). The exact sequence is proprietary.
Database link: O00625
Ab249720 is the carrier-free version of ab172629. This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.
ab249720 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.
Maxpar® is a trademark of Fluidigm Canada Inc.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Storage instructionsShipped at 4°C. Store at +4°C. Do Not Freeze.
Storage bufferConstituent: PBS
Concentration information loading...
Our Abpromise guarantee covers the use of ab249720 in the following tested applications.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 32 kDa.|
FunctionPossible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).
Tissue specificityHighly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.
PathwayFlavonoid metabolism; quercetin degradation.
Sequence similaritiesBelongs to the pirin family.
Cellular localizationNucleus. Cytoplasm. Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.
- Information by UniProt
- 3-dioxygenase PIR antibody
- Iron binding nuclear protein antibody
- Pir antibody
All lanes : Anti-Pirin/PIR antibody [EPR11376] (ab172629) at 1/1000 dilution
Lane 1 : MCF-7 cell lysate
Lane 2 : HeLa cell lysate
Lane 3 : HepG2 cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 32 kDa
This data was developed using ab172629, the same antibody clone in a different buffer formulation.
ab249720 has not yet been referenced specifically in any publications.