Overview

  • Product name

    Anti-PIST antibody - C-terminal
    See all PIST primary antibodies
  • Description

    Rabbit polyclonal to PIST - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide within Human PIST (C terminal). The exact sequence is proprietary. Conjugated to a protein carrier.
    Database link: Q9HD26

  • Positive control

    • WB: A431 whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab228652 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 51 kDa.

Target

  • Function

    Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.
  • Tissue specificity

    Ubiquitously expressed.
  • Involvement in disease

    Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
  • Sequence similarities

    Contains 1 PDZ (DHR) domain.
  • Domain

    The PDZ domain mediates interactions with FZD5, FZD8, ACCN3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1.
    The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ.
  • Cellular localization

    Cytoplasm. Golgi apparatus membrane. Golgi apparatus > trans-Golgi network membrane. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendrite. Enriched in synaptosomal and postsynaptic densities (PSD) fractions (By similarity). Expressed in cell bodies and dendrites of Purkinje cells (By similarity). Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.
  • Information by UniProt
  • Database links

  • Alternative names

    • CAL antibody
    • CFTR associated ligand antibody
    • CFTR-associated ligand antibody
    • dJ94G16.2 antibody
    • dJ94G16.2 PIST antibody
    • FIG antibody
    • Fused in glioblastoma antibody
    • Golgi associated PDZ and coiled coil motif containing antibody
    • Golgi associated PDZ and coiled coil motif containing protein antibody
    • Golgi-associated PDZ and coiled-coil motif-containing protein antibody
    • GOPC 1 antibody
    • GOPC antibody
    • GOPC_HUMAN antibody
    • GOPC1 antibody
    • OTTHUMP00000040403 antibody
    • PDZ protein interacting specifically with TC 10 antibody
    • PDZ protein interacting specifically with TC10 antibody
    • PDZ/coiled coil domain binding partner for the rho family GTPase TC 10 antibody
    • PDZ/coiled coil domain binding partner for the rho family GTPase TC10 antibody
    • PIST antibody
    • Protein interacting specifically with Tc 10 antibody
    • Protein interacting specifically with Tc10 antibody
    see all

Images

  • Anti-PIST antibody - C-terminal (ab228652) at 1/1500 dilution + A431 (human epidermoid carcinoma cell line) whole cell lysate at 30 µg

    Developed using the ECL technique.

    Predicted band size: 51 kDa



    12% SDS-PAGE

References

ab228652 has not yet been referenced specifically in any publications.

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