Overview

  • Product name

    Pitavastatin Calcium, HMG-CoA reductase inhibitor
  • Description

    Potent, competitive inhibitor of HMG-CoA reductase
  • Biological description

    Potent, competitive inhibitor of HMG-CoA reductase (Ki = 1.7nM). Blocks cholesterol synthesis. Displays cardioprotective properties. Orally active.
  • Purity

    > 98%
  • CAS Number

    147526-32-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (E,3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate hemicalcium salt
  • Molecular weight

    440.50
  • Molecular formula

    C25H23FNO4.0.5Ca
  • PubChem identifier

    5282451
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Saka M  et al. Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J Cardiovasc Pharmacol 47:770-9 (2006). Read more (PubMed: 16810078) »
  • Mukhtar RY  et al. Pitavastatin. Int J Clin Pract 59:239-52 (2005). Read more (PubMed: 15854203) »
  • Aoki T  et al. Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung 47:904-9 (1997). Read more (PubMed: 9296275) »
See all 3 Publications for this product

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