Overview

  • Product name

    Pitstop® 1, Novel clathrin inhibitor
  • Description

    Novel, selective clathrin inhibitor
  • Biological description

    Novel, selective clathrin inhibitor. Competitively inhibits clathrin terminal domain (TD) to selectively inhibit clathrin mediated endocytosis (IC50 = ~18 μM for inhibition of amphiphysin association of clathrin TD). Interferes with receptor mediated endocytosis, entry of HIV and synaptic vesicle recycling. Exhibits limited cell membrane penetration, however it is active in cells after microinjection.
  • General notes

    Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pitstop® is a trademark of Freie Universitat Berlin, Newcastle Innovation Ltd. and Children's Medical Research Institute
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • von Kleist L  et al. Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell 146:471-84 (2011). Read more (PubMed: 21816279) »
See 1 Publication for this product

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