Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Sequence
      ERMRPRKRQGSVRRRV

Specifications

Our Abpromise guarantee covers the use of ab204875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    Functional Studies

  • Form
    Lyophilised
  • Additional notes

    ab204875 (PKC epsilon peptide) can be utilized as a substrate for the following active protein kinases:

     

    ab60840 (Active human PKC beta 1 full length protein)
    ab60847 (Active human PKC epsilon full length protein)
    ab60842 (Active human PKC gamma full length protein)
    ab60849 (Active human PKC eta full length protein)
    ab56641 (Active human PKC theta full length protein)
    ab84801 (Active human STK23 full length protein)
    ab51413 (Active human MST3 protein fragment)
    ab125551 (Active human JIK protein fragment)

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Dilute peptide in distilled water to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.

General Info

  • Alternative names
    • KPCE_HUMAN
    • MGC125656
    • MGC125657
    • nPKC epsilon
    • nPKC-epsilon
    • PKCE
    • Pkcea
    • PRKCE
    • Protein kinase C epsilon
    • Protein kinase C epsilon type
    see all
  • Function
    This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.
    PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
  • Sequence similarities
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 C2 domain.
    Contains 2 phorbol-ester/DAG-type zinc fingers.
    Contains 1 protein kinase domain.
  • Domain
    The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Post-translational
    modifications
    Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729.
  • Information by UniProt

References

ab204875 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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