• Product name

  • Description

    Rabbit polyclonal to PKC iota
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide derived from the C-terminal region of mouse, rat and human PKC iota/lambda.

  • Positive control

    • Mouse spinal cord, adult and fetal mouse brain, and rat spinal cord homogenates.



Our Abpromise guarantee covers the use of ab53878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 67 kDa. N.B. Bands of unknown origin may be observed at ~85 and ~55 kDa in some homogenates.


  • Function

    Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. May play a role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. Functions in both pro- and anti-apoptotic pathways. Functions in the RAC1/ERK signaling required for transformed growth. Plays a role in microtubule dynamics through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs).
  • Tissue specificity

    Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers.
  • Sequence similarities

    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 OPR domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 protein kinase domain.
  • Domain

    The OPR domain mediates interaction with SQSTM1.
    The C1 domain does not bind diacylglycerol (DAG).
  • Post-translational

    On neuronal growth factor (NGF) stimulation, phosphorylated by Src on Tyr-265, Tyr-280 and Tyr-334. Phosphorylation on Tyr-265 facilitates binding to KPNB1/importin-beta regulating entry of PRKCI into the nucleus. Phosphorylation on Tyr-334 is important for NF-kappa-B stimulation.
  • Cellular localization

    Cytoplasm. Membrane. Endosome. Nucleus. Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by cSrc, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Vesicular tubular clusters. Transported to VTCs through interaction with RAB2A.
  • Information by UniProt
  • Database links

  • Alternative names

    • aPKC lambda/iota antibody
    • aPKC-lambda/iota antibody
    • Atypical protein kinase C lambda/iota antibody
    • Atypical protein kinase C-lambda/iota antibody
    • DXS1179E antibody
    • KPCI_HUMAN antibody
    • MGC26534 antibody
    • nPKC iota antibody
    • nPKC-iota antibody
    • nPKCiota antibody
    • PKC lambda antibody
    • PKC lambda/iota antibody
    • PKCI antibody
    • PKCiota antibody
    • PKClambda antibody
    • PRKC iota antibody
    • PRKC lambda/iota antibody
    • PRKC-lambda/iota antibody
    • PRKCI antibody
    • Protein kinase C iota antibody
    • Protein kinase C iota type antibody
    see all


ab53878 has not yet been referenced specifically in any publications.

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