Overview

  • Product name

    PKC412, Broad spectrum protein kinase inhibitor
  • Description

    Broad spectrum protein kinase inhibitor
  • Biological description

    Broad spectrum protein kinase inhibitor. Inhibits PKCα, PKCβ and PKCγ isoforms, PDFRβ, VEGFR2, Syk, PKC?, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Antitumor activity. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    120685-11-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • El Fitori J  et al. PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer. Cancer 110:1457-68 (2007). Read more (PubMed: 17676584) »
  • Tenzer A  et al. The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res 61:8203-10 (2001). Read more (PubMed: 11719451) »
  • Fabbro D  et al. PKC412--a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des 15:17-28 (2000). Read more (PubMed: 10888033) »

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