PKC412, Broad spectrum protein kinase inhibitor (ab141494)
- Datasheet
- References
Overview
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Product name
PKC412, Broad spectrum protein kinase inhibitor -
Description
Broad spectrum protein kinase inhibitor -
Biological description
Broad spectrum protein kinase inhibitor. Inhibits PKCα, PKCβ and PKCγ isoforms, PDFRβ, VEGFR2, Syk, PKC?, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Antitumor activity. Active in vivo. -
Purity
> 98% -
CAS Number
120685-11-2 -
Chemical structure
Properties
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Chemical name
N-[(5S,6R,7R,9R)-6-Methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide -
Molecular weight
570.64 -
Molecular formula
C35H30N4O4 -
PubChem identifier
9829523 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- El Fitori J et al. PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer. Cancer 110:1457-68 (2007). Read more (PubMed: 17676584) »
- Tenzer A et al. The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res 61:8203-10 (2001). Read more (PubMed: 11719451) »
- Fabbro D et al. PKC412--a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des 15:17-28 (2000). Read more (PubMed: 10888033) »
