• Product name

  • Description

    Rabbit polyclonal to PKLR
  • Host species

  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within the N terminal amino acids 1-230 of Human PKLR.

  • Positive control

    • 293T, A431, H1299, HeLa, HepG2, Raji cell lysates



Our Abpromise guarantee covers the use of ab96604 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 62 kDa.
ICC/IF 1/100 - 1/200.


  • Function

    Plays a key role in glycolysis.
  • Pathway

    Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.
  • Involvement in disease

    Defects in PKLR are the cause of pyruvate kinase hyperactivity (PKHYP) [MIM:102900]; also known as high red cell ATP syndrome. This autosomal dominant phenotype is characterized by increase of red blood cell ATP.
    Defects in PKLR are the cause of pyruvate kinase deficiency of red cells (PKRD) [MIM:266200]. A frequent cause of hereditary non-spherocytic hemolytic anemia. Clinically, pyruvate kinase-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at birth, severe transfusion-dependent chronic hemolysis, moderate hemolysis with exacerbation during infection, to a fully compensated hemolysis without apparent anemia.
  • Sequence similarities

    Belongs to the pyruvate kinase family.
  • Information by UniProt
  • Database links

  • Alternative names

    • EC antibody
    • KPYR_HUMAN antibody
    • L-PK antibody
    • Pk-1 antibody
    • PK1 antibody
    • PKL antibody
    • Pklg antibody
    • Pklr antibody
    • PKR antibody
    • PKRL antibody
    • Pyruvate kinase 1 antibody
    • Pyruvate kinase isozymes R/L antibody
    • Pyruvate kinase liver and blood cell antibody
    • Pyruvate kinase liver and RBC antibody
    • Pyruvate kinase liver and red blood cell antibody
    • Pyruvate kinase liver type antibody
    • Pyruvate kinase type L antibody
    • Pyruvate kinase, red cell type antibody
    • R type/L type pyruvate kinase antibody
    • R-PK antibody
    • R-type/L-type pyruvate kinase antibody
    • Red cell/liver pyruvate kinase antibody
    • RPK antibody
    see all


  • All lanes : Anti-PKLR antibody (ab96604) at 1/5000 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 62 kDa

    7.5% SDS PAGE
  • Immunofluorescence analysis of paraformaldehyde-fixed A431, using ab96604 at 1:200 dilution. Image 2: Merged with DNA probe.


ab96604 has not yet been referenced specifically in any publications.

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