PKSI-527, plasma kallikrein inhibitor (ab144543)

Overview

  • Product name

    PKSI-527, plasma kallikrein inhibitor
  • Description

    Selective plasma kallikrein inhibitor
  • Biological description

    Selective plasma kallikrein inhibitor (Ki = 0.81 μM). Synergizes with NO donors. Shows antiarthritic, vasodilatory and antithrombotic effects in vivo.
  • Purity

    > 95%
  • CAS Number

    128837-71-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide
  • Molecular weight

    474.00
  • Molecular formula

    C25H31N3O4.HCl
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.NC[C@@H]1CC[C@H](CC1)C(=O)NC(Cc2ccccc2)C(=O)Nc3ccc(CC(=O)O)cc3
  • Source

    Synthetic

References

This product has been referenced in:

  • Jones RG  et al. Release of proteolytic activity following reduction in therapeutic human serum albumin containing products: detection with a new neoepitope endopeptidase immunoassay. J Pharm Biomed Anal 54:74-80 (2011). Read more (PubMed: 20832960) »
  • Sasaoka T  et al. Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts. J Cardiovasc Pharmacol 52:176-83 (2008). Read more (PubMed: 18670361) »
  • Marangoni RA  et al. Role of the kallikrein-kinin system in Ang-(1-7)-induced vasodilation in mesenteric arterioles of Wistar rats studied in vivo-in situ. Peptides 27:1770-5 (2006). Read more (PubMed: 16595159) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144543.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up