Overview

  • Product name

  • Description

    Rabbit polyclonal to PLA1A/NMD
  • Host species

    Rabbit
  • Specificity

    At least three isoforms of PLA1A/NMD are known to exist; ab139728 will detect all three isoforms.

  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human PLA1A/NMD (C terminal).
    Database link: NP_056984

  • Positive control

    • Human kidney tissue lysate.
  • General notes

     This product was previously labelled as PLA1A

     

Properties

Applications

Our Abpromise guarantee covers the use of ab139728 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 50 kDa.
ICC/IF Use a concentration of 20 µg/ml.

Target

  • Function

    Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.
  • Tissue specificity

    Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.
  • Sequence similarities

    Belongs to the AB hydrolase superfamily. Lipase family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • AA986889 antibody
    • NMD antibody
    • OTTHUMP00000215248 antibody
    • OTTHUMP00000215249 antibody
    • OTTHUMP00000215250 antibody
    • Phosphatidylserine specific phospholipase A1 antibody
    • Phosphatidylserine specific phospholipase A1alpha antibody
    • Phosphatidylserine-specific phospholipase A1 antibody
    • Phospholipase A1 member A antibody
    • pla1a antibody
    • PLA1A_HUMAN antibody
    • PS PLA1 antibody
    • PS-PLA1 antibody
    • PSPLA 1 antibody
    • PSPLA1 antibody
    see all

Images

  • Immunofluorescence of PLA1A/NMD in Human kidney tissue with ab139728 at 20 ug/mL.

  • Lane 1 : Anti-PLA1A/NMD antibody (ab139728) at 1 µg/ml
    Lane 2 : Anti-PLA1A/NMD antibody (ab139728) at 2 µg/ml

    All lanes : Human kidney tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 50 kDa

References

This product has been referenced in:

  • Abu El-Asrar AM  et al. Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy. Lipids Health Dis 13:187 (2014). Read more (PubMed: 25496321) »
See 1 Publication for this product

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